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80

抑制剂 & 化合物

38

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T7474	7-Nitroindazole	NOS	Immunology/Inflammation
	7-Nitroindazole 是一种具有抗损伤及心血管作用的选择性nNOS 抑制剂，也是评价一氧化氮在中枢神经系统中生物学效应的有效工具。
T10107	3-Bromo-7-nitroindazole	NOS	Immunology/Inflammation
	3-Bromo-7-nitroindazole 是有效的、选择性的神经元型一氧化氮合酶抑制剂，对 eNOS 或诱导型一氧化氮合酶的效果相对较弱。3-Bromo-7-nitroindazole 对全身和大脑中的细胞间信使一氧化氮的合成都有影响。
T1322	Bendazol 地巴唑,Dibazol,Dibazole	Dopamine Receptor; NO Synthase	GPCR/G Protein; Immunology/Inflammation; Neuroscience
	Bendazol (Dibazol) 是降压药物，能够提高 NO 合成酶在肾小球和集合小管中的活性。
T22724	Dimaprit dihydrochloride	NOS; NO Synthase; Histamine Receptor	GPCR/G Protein; Immunology/Inflammation; Neuroscience
	Dimaprit dihydrochloride 是组胺H2受体的一种选择性激动剂，可刺激胃酸的分泌。它还抑制nNOS，IC50值为 49 μM。
T1479	Isosorbide dinitrate 硝酸异山梨酯,Isordil,Nitrosorbide,Sorbide nitrate,Sorbidnitrate	Others; NO Synthase	Immunology/Inflammation; Others
	Isosorbide dinitrate (Isordil) 是 NO 供体，可预防心肌梗死 (MI) 引起的左室重构及心功能退化。
T15697	L-NMMA acetate Tilarginine acetate,Methylarginine acetate	NOS	Immunology/Inflammation
	L-NMMA acetate (Tilarginine acetate) 是一氧化氮合酶抑制剂, 对其所有亚型均有抑制作用，包括 NOS1，NOS2和 NOS3。与 nNOS (大鼠), eNOS (人), 和 iNOS (小鼠)结合的 Ki 值分别为0.18，0.4，6 µM。
T21507	7-Ethoxyresorufin Resorufin ethyl ether,乙氧基试卤灵	P450; NO Synthase	Immunology/Inflammation; Metabolism
	7-Ethoxyresorufin (Resorufin ethyl ether) 是细胞色素 P450 (尤其是CYP1A1) 的荧光底物和竞争性抑制剂，同时对 NO 合酶具有抑制作用。
T3491	1400W dihydrochloride 1400W 2HCl,N-(3-(Aminomethyl)benzyl)acetamidine	NOS; NO Synthase	Immunology/Inflammation
	1400W dihydrochloride (N-(3-(Aminomethyl)benzyl)acetamidine) 是高效选择性的诱导型一氧化氮合成酶抑制剂(Ki:7 nM)。
T19853	Dimethoxycurcumin Veratrylcurcuminoid,二甲氧基姜黄素	Others	Others
	Dimethoxycurcumin (Veratrylcurcuminoid) 是 curcumin 衍生物，拥有抗氧化及抗炎作用。
T21700	NOS-IN-1 2-Imino-4-methylpiperidine (acetate)	NOS	Immunology/Inflammation
	NOS-IN-1 (2-Imino-4-methylpiperidine acetate) 是有效的、具有口服活性的一氧化氮合酶 (NOS) 的抑制剂。NOS-IN-1抑制人 iNOS (hiNOS)，hnNOS 和 heNOS 的 IC50 分别为 0.1 μM，0.2 μM 和1.1 μM。
T2334	Avanafil 阿伐那非,TA1790	PDE	Metabolism
	Avanafil (TA1790) 是一种高活性PDE-5抑制剂，IC50=5.2 nM，对PDE1，PDE6和PDE11活性较低。
T12808	S-Nitroso-N-acetyl-DL-penicillamine N-乙酰基-3-(硫代亚硝基)-DL-缬氨酸,SNAP	NO Synthase	Immunology/Inflammation
	S-Nitroso-N-acetyl-DL-penicillamine (SNAP) 是一种稳定的血小板聚集抑制剂，是一氧化氮的供体。
T7206L	2-Iminobiotin hydrobromide 2-亚氨基生物素,Guanidinobiotin,2-亚氨基生物素盐酸盐	NOS; NO Synthase	Immunology/Inflammation
	2-Iminobiotin hydrobromide (Guanidinobiotin) 是生物素 (维生素 H 或 B7) 类似物。它是一种可逆的 NO 合酶抑制剂，可作用于小鼠 iNOS(Ki:21.8 μM)和大鼠 n-cNOS(Ki:37.5 μM)。它和低温环境均可以保护人类神经细胞，使其免受缺氧诱导的细胞损伤。
T7461	2,4-Diamino-6-hydroxypyrimidine DAHP,2,4-二氨基-6-羟基嘧啶	Reactive Oxygen Species; NO Synthase	Immunology/Inflammation; Metabolism; NF-κB
	2,4-Diamino-6-hydroxypyrimidine (DAHP) 是GTP cyclohydrolase I(蛋白从头合成中的限速酶) 的选择性抑制剂。它能够抑制NO 的产生以及阻断 Tetrahydrobiopterin (BH4) 的合成。
T19916	TRIM 1-(2-Trifluoromethylphenyl)imidazole,1-(2-三氟甲基苯基)咪唑	NOS	Immunology/Inflammation
	TRIM (1-(2-Trifluoromethylphenyl)imidazole) 是一氧化氮合酶抑制剂。它在体外能够抑制小鼠小脑 nNOS (IC50:28.2 µM)，以及大鼠肺 iNOS (IC50:27.0 µM)。它拥有抗焦虑以及抗抑郁的能力。
T3198L	PRE-084 hydrochloride	Sigma receptor	GPCR/G Protein
	PRE-084 hydrochloride 是 σ1 的选择性激动剂在sigma 受体检测中，IC50值为44 nM。
T10404	ATP synthase inhibitor 1	ATPase	Membrane transporter/Ion channel
	ATP synthase inhibitor 1 是 F1/FO-ATP 合酶复合物 c 亚基的有效抑制剂，抑制线粒体通透性转换孔的开放。
T1102	Mifepristone C-1073,RU486,RU 38486,米非司酮	Glucocorticoid Receptor; Estrogen/progestogen Receptor; Progesterone Receptor; NO Synthase; Autophagy	Autophagy; Endocrinology/Hormones; Immunology/Inflammation; Others
	Mifepristone (C-1073) 是一种黄体酮受体和糖皮质激素受体拮抗剂，在体外实验中的 IC50值分别为 0.2 nM 和 2.6 nM。
T22419	S-Methylisothiourea sulfate (S)-Methylisothiourea sulfate,S-甲基异硫脲硫酸盐,S-甲基异硫脲半硫酸盐	NOS; NO Synthase; HSV	Immunology/Inflammation; Microbiology/Virology
	S-Methylisothiourea sulfate ((S)-Methylisothiourea sulfate) 是一种选择性 iNOS 抑制剂，在感染性休克的啮齿动物模型中发挥有益作用。
T4380	Ac-CoA Synthase Inhibitor1 ACSS2 inhibitor	RSV; Fatty Acid Synthase	Metabolism; Microbiology/Virology
	Ac-CoA Synthase Inhibitor1 (ACSS2 inhibitor) 是一种可逆的醋酸盐依赖性乙酰辅酶 A 合成酶 2 抑制剂，IC50为 0.6 µM，可抑制呼吸道合胞病毒。
T0006	Methylene Blue trihydrate 碱性亚甲蓝三水合物,Methylthionine chloride,Basic blue 9,亚甲蓝三水合物,Methylene Blue	Guanylate cyclase; Microtubule Associated; NO Synthase; Parasite; Monoamine Oxidase	Cytoskeletal Signaling; GPCR/G Protein; Immunology/Inflammation; Microbiology/Virology; Neuroscience
	Methylene Blue trihydrate (Basic blue 9) 是鸟苷酸环化酶，单胺氧化酶 A 和 NO 合酶抑制剂。它是血管加压药，在医疗中通常用作染料。它具有抗伤害感受，抗疟疾，抗抑郁和抗焦虑作用，可用于高铁血红蛋白血症，神经退行性疾病和异环磷酰胺引起的脑病的研究。
T6888	Methylene Blue 亚甲蓝,methylthioninium chloride,CI-52015,Tetramethylthionine chloride,亚甲兰,Basic Blue 9	Guanylate cyclase; Microtubule Associated; NO Synthase; Parasite; Monoamine Oxidase	Cytoskeletal Signaling; GPCR/G Protein; Immunology/Inflammation; Microbiology/Virology; Neuroscience
	Methylene Blue (Tetramethylthionine chloride) 是鸟苷酸环化酶，是单胺氧化酶 A 和 NO 合酶抑制剂。它有抗伤害感受、抗疟疾、抗抑郁和抗焦虑作用，可研究高铁血红蛋白血症、神经退行性疾病和异环磷酰胺引起的脑病。它是血管加压剂，用作色素内窥镜检查中的染料。
T0358	Aminoguanidine hydrochloride Imino semicarbazide,Pimagedine hydrochloride,CP-12009-18 tartrate,Hydrazinecarboximidamide,肼甲酰亚胺酰胺一氯化氢（氨基胍盐酸盐）,氨基胍盐酸盐,Guanyl hydrazine,Pimagedine	NOS; NO Synthase	Immunology/Inflammation
	Aminoguanidine hydrochloride (Hydrazinecarboximidamide) 是二胺氧化酶抑制剂，也是一氧化氮合酶抑制剂，可用于糖尿病肾病的研究。
T6570	L-NAME hydrochloride L-NAME HCl,N'-硝基-L-精氨酸甲酯盐酸盐,N(G)-Nitro-L-arginine methyl ester,NG-Nitroarginine methyl ester hydrochloride	NOS; NO Synthase	Immunology/Inflammation
	L-NAME hydrochloride (L-NAME HCl) 是NOS 抑制剂(IC50:70 μM)。
T3211	Midostaurin 米哚妥林,N-Benzoylstaurosporine,PKC412,CGP41231,CGP 41251,苯甲酰基十字孢碱	Others; PKC	Chromatin/Epigenetic; Cytoskeletal Signaling; Others
	Midostaurin (PKC412) 是一种多靶点蛋白激酶抑制剂，有抗肿瘤活性，对 PKCα/β/γ、Syk、Flk-1、Akt、PKA、c-Kit、c-Fgr、c-Src、FLT3、PDFRβ和VEGFR1/2的IC50值范围为 22 到500 nM 之间。
T9537	N'-Nitro-D-arginine N'-Nitro-D-arginine,H-D-Arg(NO2)-OH,(R)-2-Amino-5-(3-nitroguanidino)pentanoic acid,N'-硝基-D-精氨酸	Others	Others
	N'-Nitro-D-arginine (N'-Nitro-D-arginine) 是一种砌块。
T7206	2-Iminobiotin 2-IMINOBIOTIN HYDROBROMIDE,2-亚氨基生物素,Guanidinobiotin	NOS; NO Synthase	Immunology/Inflammation
	2-Iminobiotin (Guanidinobiotin) 是一种生物素 (维生素 H 或 B7) 类似物。它是一种可逆的 NO 合酶抑制剂，能够作用于小鼠 iNOS(Ki:21.8 μM)及大鼠 n-cNOS(Ki:37.5 μM)。它和低温环境均可以保护人类神经细胞，使其免受缺氧诱导的细胞损伤。
T39693	Polyketide synthase 13-IN-3
	Polyketide synthase 13-IN-3 (compound 41) is a potent inhibitor of polyketide synthase 13, demonstrating a minimum inhibitory concentration (MIC) range of 0.0625-0.125 μg/mL against the M. tuberculosis strain H37Rv.
T39883	Polyketide synthase 13-IN-1
	Polyketide synthase 13-IN-1 (compound 32) is a polyketide synthase 13 inhibitor.
T75397	Hyaluronan synthase (PmHAS)
	Hyaluronan synthase (PmHAS)为膜蛋白，依赖Mg+2及两种糖-UDP底物（GlcUA-UDP与GlcNAc-UDP）合成HA链。该酶负责透明质酸(HA)的生物合成。
T62475	Chitin synthase inhibitor 7
	Chitin synthase inhibitor 7 (compound 9c) 是一种 chitin synthase (CHS) 的有效抑制剂 (IC50: 0.37 nM)。Chitin synthase inhibitor 7 对耐药真菌具有广谱抗真菌作用。Chitin synthase inhibitor 7 能够用于研究真菌感染。
T79481	Chitin synthase inhibitor 13
	Chitin synthase inhibitor 13 (compound 12g) 为非竞争性几丁质合酶抑制剂，其IC50为106.7 μM，展现出广谱抗真菌活性。
T61398	Chitin synthase inhibitor 3
	Chitin synthase inhibitor 3 (compound 2d) 是一种高效的chitin synthase抑制剂，具有0.16 mM的IC50值，并对candida albicans显示出1 μg/mL的MIC，表现出抗真菌活性。
T61649	ATP synthase inhibitor 2
	ATP synthase inhibitor2 是一个铜绿假单胞菌 (PA)ATP synthase 抑制剂 (IC50=10 μg/mL)，在 128 μg/mL 时可完全抑制铜绿假单胞菌 (PA) 的 ATP 合成活性。
T62246	Chitin synthase inhibitor 8
	Chitin synthase inhibitor 8 是一种 chitin synthase (CHS) 抑制剂，具有广谱抗真菌作用，能够用于真菌感染相关研究。
T63353	Chitin synthase inhibitor 11
	Chitin synthase inhibitor 11 是一种高效的几丁质合酶 (CHS) 抑制剂，能够明显抑制 CHS 的活性 (IC50: 0.10 mM)，具有广谱体外抑菌作用。Chitin synthase inhibitor 11 能够用于研究侵袭性真菌感染 (IFIs)。
T62738	Chitin synthase inhibitor 6
	Chitin synthase inhibitor 6 (compound 9b) 是一种 chitin synthase (CHS) 的有效抑制剂 (IC50: 0.21 mM)。Chitin synthase inhibitor 6 对耐药真菌表现出广谱抗真菌效果，能够用于研究真菌感染。
T81109	Squalene synthase-IN-1
	Squalene synthase-IN-1（compound 1）是一种通过抑制Squalene Synthase来发挥降血脂作用的有效药物。该化合物也展现了卓越的抗氧化和抗炎特性，能显著降低葡萄糖水平和氧化应激，且不引起毒性。
T62664	Glucosylceramide synthase-IN-2
	Glucosylceramide synthase-IN-2 (compound T-690) 是一种有效的、具有血脑屏障通透性的、口服具有活力的 glucosylceramide synthase (GCS) 抑制剂，作用于人 GCS (IC50: 15 nM) 和小鼠 GCS (IC50: 190 nM)。Glucosylceramide synthase-IN-2 能够非竞争性抑制 C8 神经酰胺和 UDP 葡萄糖。Glucosylceramide synthase-IN-2 能够用于研究戈谢病。
T62701	Dihydropteroate synthase-IN-1
	Dihydropteroate synthase-IN-1 (compound 5g) 是一种dihydropteroate synthase (DHPS) 的有效抑制剂，对细胞色素 P450 具有抑制作用。Dihydropteroate synthase-IN-1 具有抗微生物活性和抗真菌作用。Dihydropteroate synthase-IN-1 能够用作放射诊断影像材料。
T63392	Chitin synthase inhibitor 5
	Chitin synthase inhibitor 5 是一种几丁质合成酶的抑制剂 (IC50: 0.14 mM)。Chitin synthase inhibitor 5 表现出广谱的真菌抗活性，能够较好的抑制白色念珠菌、黄曲霉、烟毒念珠菌和新生念珠菌，能够用于研究真菌。
T62068	Chitin synthase inhibitor 1
	Chitin synthase inhibitor 1 是有效的、选择性的几丁质合酶 (CHS) 抑制剂，IC50值为0.12 mM。Chitin synthase inhibitor 1 强效抑制耐药真菌变体。
T38168	S.pombe lumazine synthase-IN-1
	S.pombe lumazine synthase-IN-1 is an inhibitor of lumazine synthases with Ki values of 243 μM and 9.6 μM for Schizosaccharomyces pombe and Mycobacterium tuberculosis lumazine synthases, respectively[1]. [1]. Arindam Talukdar, et al. Discovery and Development of a Small Molecule Library With Lumazine Synthase Inhibitory Activity. J Org Chem. 2009 Aug 7;74(15):5123-34.
T63077	Chitin synthase inhibitor 12
	Chitin synthase inhibitor 12 是一种几丁质合酶 (CHS) 抑制剂，具有优异的 CHS 抑制作用 (IC50: 0.16 mM)。Chitin synthase inhibitor 12 也是一种广谱抗真菌剂，对耐药真菌变体（如 C. albicans、C. neoformans）具有抗性。Chitin synthase inhibitor 12 能够用于研究侵袭性真菌感染 (IFIs)。
T61632	Glucosylceramide synthase-IN-3
	Glucosylceramide synthase-IN-3 (compound BZ1) is a highly potent, brain-penetrant, and orally active inhibitor of glucosylceramide synthase (GCS), exhibiting an IC50 value of 16 nM for human GCS. This compound, designated as Glucosylceramide synthase-IN-3, finds potential applications in Gaucher's disease research [1] [2].
T61188	Chitin synthase inhibitor 2
	Chitin synthase inhibitor 2 (compound 2b) is a highly potent inhibitor of chitin synthase, with an IC50 value of 0.09 mM and a K i value of 0.12 mM. This compound exhibits antimicrobial activities in vitro and demonstrates synergistic or additive effects when combined with fluconazole or polyoxin B [1].
T62898	Glucosylceramide synthase-IN-1
	Glucosylceramide synthase-IN-1 (T-036) 是一种有效的、口服具有活力的、具有血脑屏障通透性的 glucosylceramide synthase (GCS) 抑制剂，作用于人 GCS (IC50: 31 nM) 和小鼠 GCS (IC50: 51 nM)。Glucosylceramide synthase-IN-1 能够用于研究戈谢病。
T62739	Chitin synthase inhibitor 9
	Chitin synthase inhibitor 9 是一种几丁质合成酶 (chitin synthase, CHS) 抑制剂，表现出广谱抗真菌效果。Chitin synthase inhibitor 9 能够用于进行真菌感染相关研究。
T78886	Chitin synthase inhibitor 14
	Chitin synthase inhibitor 14 (compound 4n)，一种CHS抑制剂，展现出优异的抗真菌活性和对耐药真菌变异的有效抗性。
T74956	Chitin synthase inhibitor 10
	Chitin synthase inhibitor 10为一种高效的几丁质合酶(CHS)抑制剂，具有0.11 mM的IC50，表现出显著的CHS抑制活性。作为抗真菌剂，该化合物对包括C. albicans和C. neoformans在内的耐药真菌变体有效，适合用于侵袭性真菌感染(IFI)研究。

化合物

7-Nitroindazole

Cat.No: T7474

Target: NOS

3-Bromo-7-nitroindazole

Cat.No: T10107

Target: NOS

Cat.No: T1322

Synonym: 地巴唑,Dibazol,Dibazole

Target: Dopamine Receptor, NO Synthase

Dimaprit dihydrochloride

Cat.No: T22724

Target: NOS, NO Synthase, Histamine Receptor

Isosorbide dinitrate

Cat.No: T1479

Synonym: 硝酸异山梨酯,Isordil,Nitrosorbide,Sorbide nitrate,Sorbidnitrate

Target: Others, NO Synthase

Cat.No: T15697

Synonym: Tilarginine acetate,Methylarginine acetate

Target: NOS

7-Ethoxyresorufin

Cat.No: T21507

Synonym: Resorufin ethyl ether,乙氧基试卤灵

Target: P450, NO Synthase

1400W dihydrochloride

Cat.No: T3491

Synonym: 1400W 2HCl,N-(3-(Aminomethyl)benzyl)acetamidine

Target: NOS, NO Synthase

Dimethoxycurcumin

Cat.No: T19853

Synonym: Veratrylcurcuminoid,二甲氧基姜黄素

Target: Others

Cat.No: T21700

Synonym: 2-Imino-4-methylpiperidine (acetate)

Target: NOS

Cat.No: T2334

Synonym: 阿伐那非,TA1790

Target: PDE

S-Nitroso-N-acetyl-DL-penicillamine

Cat.No: T12808

Synonym: N-乙酰基-3-(硫代亚硝基)-DL-缬氨酸,SNAP

Target: NO Synthase

2-Iminobiotin hydrobromide

Cat.No: T7206L

Synonym: 2-亚氨基生物素,Guanidinobiotin,2-亚氨基生物素盐酸盐

Target: NOS, NO Synthase

2,4-Diamino-6-hydroxypyrimidine

Cat.No: T7461

Synonym: DAHP,2,4-二氨基-6-羟基嘧啶

Target: Reactive Oxygen Species, NO Synthase

Cat.No: T19916

Synonym: 1-(2-Trifluoromethylphenyl)imidazole,1-(2-三氟甲基苯基)咪唑

Target: NOS

PRE-084 hydrochloride

Cat.No: T3198L

Target: Sigma receptor

ATP synthase inhibitor 1

Cat.No: T10404

Target: ATPase

Cat.No: T1102

Synonym: C-1073,RU486,RU 38486,米非司酮

Target: Glucocorticoid Receptor, Estrogen/progestogen Receptor, Progesterone Receptor, NO Synthase, Autophagy

S-Methylisothiourea sulfate

Cat.No: T22419

Synonym: (S)-Methylisothiourea sulfate,S-甲基异硫脲硫酸盐,S-甲基异硫脲半硫酸盐

Target: NOS, NO Synthase, HSV

Ac-CoA Synthase Inhibitor1

Cat.No: T4380

Synonym: ACSS2 inhibitor

Target: RSV, Fatty Acid Synthase

Methylene Blue trihydrate

Cat.No: T0006

Synonym: 碱性亚甲蓝三水合物,Methylthionine chloride,Basic blue 9,亚甲蓝三水合物,Methylene Blue

Target: Guanylate cyclase, Microtubule Associated, NO Synthase, Parasite, Monoamine Oxidase

Cat.No: T6888

Synonym: 亚甲蓝,methylthioninium chloride,CI-52015,Tetramethylthionine chloride,亚甲兰,Basic Blue 9

Target: Guanylate cyclase, Microtubule Associated, NO Synthase, Parasite, Monoamine Oxidase

Aminoguanidine hydrochloride

Cat.No: T0358

Synonym: Imino semicarbazide,Pimagedine hydrochloride,CP-12009-18 tartrate,Hydrazinecarboximidamide,肼甲酰亚胺酰胺一氯化氢（氨基胍盐酸盐）,氨基胍盐酸盐,Guanyl hydrazine,Pimagedine

Target: NOS, NO Synthase

L-NAME hydrochloride

Cat.No: T6570

Synonym: L-NAME HCl,N'-硝基-L-精氨酸甲酯盐酸盐,N(G)-Nitro-L-arginine methyl ester,NG-Nitroarginine methyl ester hydrochloride

Target: NOS, NO Synthase

Cat.No: T3211

Synonym: 米哚妥林,N-Benzoylstaurosporine,PKC412,CGP41231,CGP 41251,苯甲酰基十字孢碱

Target: Others, PKC

N'-Nitro-D-arginine

Cat.No: T9537

Synonym: N'-Nitro-D-arginine,H-D-Arg(NO2)-OH,(R)-2-Amino-5-(3-nitroguanidino)pentanoic acid,N'-硝基-D-精氨酸

Target: Others

Cat.No: T7206

Synonym: 2-IMINOBIOTIN HYDROBROMIDE,2-亚氨基生物素,Guanidinobiotin

Target: NOS, NO Synthase

Polyketide synthase 13-IN-3

Cat.No: T39693

Polyketide synthase 13-IN-1

Cat.No: T39883

Hyaluronan synthase (PmHAS)

Cat.No: T75397

Chitin synthase inhibitor 7

Cat.No: T62475

Chitin synthase inhibitor 13

Cat.No: T79481

Chitin synthase inhibitor 3

Cat.No: T61398

ATP synthase inhibitor 2

Cat.No: T61649

Chitin synthase inhibitor 8

Cat.No: T62246

Chitin synthase inhibitor 11

Cat.No: T63353

Chitin synthase inhibitor 6

Cat.No: T62738

Squalene synthase-IN-1

Cat.No: T81109

Glucosylceramide synthase-IN-2

Cat.No: T62664

Dihydropteroate synthase-IN-1

Cat.No: T62701

Chitin synthase inhibitor 5

Cat.No: T63392

Chitin synthase inhibitor 1

Cat.No: T62068

S.pombe lumazine synthase-IN-1

Cat.No: T38168

Chitin synthase inhibitor 12

Cat.No: T63077

Glucosylceramide synthase-IN-3

Cat.No: T61632

Chitin synthase inhibitor 2

Cat.No: T61188

Glucosylceramide synthase-IN-1

Cat.No: T62898

Chitin synthase inhibitor 9

Cat.No: T62739

Chitin synthase inhibitor 14

Cat.No: T78886

Chitin synthase inhibitor 10

Cat.No: T74956

Cat. No.	Product Name	Target	Signaling Pathways
TQ0301	Kuwanon A	NO Synthase	Immunology/Inflammation
	Kuwanon A 抑制一氧化氮的产生 (IC50: 10.5 μM)。Kuwanon A 是从桑树 (Morus alba L.) 中分离出来的黄酮衍生物。
T6S1665	Irisflorentin	Others; NO Synthase	Immunology/Inflammation; Others
	Irisflorentin 是天然存在的异黄酮，是大量存在于 Rhizoma Belamcandae 中的活性成分。它明显抑制了诱导型一氧化氮合酶的转录和翻译以及 NO 产生。
T6S2023	Harpagoside	Others; COX; NO Synthase	Immunology/Inflammation; Neuroscience; Others
	Harpagoside 是从爪钩草中分离出来的一种天然产物，可抑制COX-1和COX-2活性，并抑制 NO 的产生。
T7682	Asymmetric dimethylarginine	Endogenous Metabolite; NO Synthase; NOD	Immunology/Inflammation; Metabolism; NF-κB
	Asymmetric dimethylarginine 是内源性一氧化氮合成酶抑制剂，可以作为内皮功能障碍的标志。
T2S0765	Epibetulinic acid	NO Synthase; Prostaglandin Receptor	GPCR/G Protein; Immunology/Inflammation
	Epibetulinic acid 对细菌内毒素刺激的小鼠巨噬细胞 (RAW 264.7) 中 NO 和前列腺素 E(2) 的产生具有有效的抑制作用，IC50分别为 0.7 和 0.6 μM，具有抗炎活性。
T3847	Asperuloside Asperulosid,车叶草苷	Others; NO Synthase	Immunology/Inflammation; Others
	Asperuloside (Asperulosid) 是一种来源于蛇舌草的环烯醚萜，具有抗炎作用。它可抑制诱导型一氧化氮合酶，抑制 NF-κB 和 MAPK 信号通路。
T2S2335	Dehydroevodiamine DHED,去氢吴茱萸碱	Others; NF-κB; COX; PGE Synthase; NO Synthase	Immunology/Inflammation; Neuroscience; NF-κB; Others
	Dehydroevodiamine (DHED) 是从吴茱萸中分离出的一种喹唑啉生物碱，可抑制 LPS 诱导的小鼠巨噬细胞中iNOS、COX-2、PGE2和NF-κB 的表达，对豚鼠心室肌细胞具有抗心律失常作用。
T5838	L-Canavanine sulfate	NO Synthase; NOD	Immunology/Inflammation; NF-κB
	L-Canavanine sulfate 是一种诱导型 NO 合酶的选择性抑制剂。
T5S0285	Cistanoside A 肉苁蓉苷 A,肉苁蓉苷A	Others	Others
	Cistanoside A 是一种肉苁蓉中的苯丙素类化合物，能够抑制 NO 的聚集，但不影响诱导型一氧化氮合酶 iNOS 的 mRNA 和蛋白水平及其活性。它具有抗炎作用。
T5681	ETHYL CAFFEATE 咖啡酸乙酯,ETHYL 3,4-DIHYDROXYCINNAMATE	NF-κB; COX; PGE Synthase; NO Synthase	Immunology/Inflammation; Neuroscience; NF-κB
	Ethyl Caffeate (ETHYL 3,4-DIHYDROXYCINNAMATE) 是从鬼针草分离的一种酚类天然产物，在体外或在小鼠皮肤中抑制NF-κB 活化及其下游炎症介质的诱导型一氧化氮合酶、环氧合酶 2 和前列腺素 E2。
T4808	Agmatine sulfate Agmatine sulfate salt,硫酸胍基丁胺	Endogenous Metabolite; NO Synthase; Imidazoline Receptor	Immunology/Inflammation; Metabolism; Neuroscience
	Agmatine sulfate (Agmatine sulfate salt) 是咪唑啉受体的内源性激动剂和一氧化氮合酶抑制剂。它靶向神经递质系统，离子通道和一氧化氮合成。
T7597	6-Biopterin L-生物喋呤,L-Biopterin	Endogenous Metabolite; NO Synthase; NOD	Immunology/Inflammation; Metabolism; NF-κB
	6-Biopterin (L-Biopterin) 是一种蝶呤衍生物，是一氧化氮合酶 (NO synthase) 辅因子。
T2791	Pectolinarin 柳穿鱼叶苷,大蓟苷	Apoptosis; Others; NO Synthase; Prostaglandin Receptor; Interleukin	Apoptosis; GPCR/G Protein; Immunology/Inflammation; Others
	Pectolinarin 抑制 IL-6和 IL-8分泌以及 PGE2和 NO 产生，可通过抑制 PI3K/Akt 途径来抑制细胞增殖和炎症反应并诱导凋亡，具有抗炎活性。
TN2139	Regaloside B 鸦胆子苦醇,王百合苷 B	NOS; COX; NO Synthase	Immunology/Inflammation; Neuroscience
	Regaloside B 是从麝香百合中分离出来的一种苯丙烷，可抑制iNOS 和COX-2的表达，具有抗炎活性。
T2980	Chondroitin sulfate Chonsurid,Chondroitin polysulfate,硫酸软骨素	MMP; Others; Endogenous Metabolite; NO Synthase	Immunology/Inflammation; Metabolism; Others; Proteases/Proteasome
	Chondroitin sulfate (Chonsurid) 是一种糖胺聚糖，被广泛用于骨关节炎的研究。它能够减少炎症介质和凋亡过程，并能够减少炎性细胞因子，iNOS 和MMPs 产生。
T3S0364	L-Arginine L-精氨酸,L-Arg,(S)-(+)-Arginine	IL Receptor; Endogenous Metabolite; NO Synthase	Immunology/Inflammation; Metabolism
	L-Arginine (L-Arg) 是内皮型一氧化氮合酶(eNOS) 的底物。L-Arginine 通过阳离子氨基酸转运体家族转运到血管平滑肌细胞，并被代谢成一氧化氮、多胺或 L-脯氨酸。
T1310	2-Thiouracil Thiouracil,硫代由雪,Deracil,2-硫脲嘧啶	Thyroid hormone receptor(THR); NO Synthase	Endocrinology/Hormones; Immunology/Inflammation
	2-Thiouracil (Deracil) 是神经型一氧化氮合酶 (nNOS) 的选择性抑制剂(Ki:20 μM)，是一种抗甲状腺化合物，可用作高度特异性的黑色素瘤探测物。
TN1373	α-Humulene Alpha-caryophyllene,ALPHA-律草烯	TNF; NOS; COX	Apoptosis; Immunology/Inflammation; Neuroscience
	α-Humulene (Alpha-caryophyllene) 是 Tanacetum vulgareL. 精油的主要成分，显示出抗炎作用，IC50=15±2 μg/mL。它抑制 iNOS 和COX-2表达。
T5684	Ethyl 3,4-dihydroxybenzoate	Apoptosis; Others; Reactive Oxygen Species; HIF/HIF Prolyl-Hydroxylase; NO Synthase; Autophagy	Apoptosis; Autophagy; Chromatin/Epigenetic; Immunology/Inflammation; Metabolism; NF-κB; Others
	Ethyl 3,4-dihydroxybenzoate 是从花生种子的种皮中发现的脯氨酰羟化酶抑制剂，是一种抗氧化剂。它是胶原蛋白合成抑制剂，具有骨骼保护作用。它通过激活 NO 合酶并产生线粒体 ROS 来保护心肌，可诱导 ESCC 细胞自噬和凋亡。
T7030	anemarsaponin B 知母皂苷B,知母皂苷 B	p38 MAPK; NF-κB; MEK; COX; NO Synthase	Immunology/Inflammation; MAPK; Neuroscience; NF-κB
	Anemarsaponin B 是一种甾体皂苷，可降低iNOS 和COX-2的蛋白和 mRNA 水平，减少促炎细胞因子的表达和产生。它通过阻断 IκBα 的磷酸化来抑制NF-κB 的 p65 亚基的核转位，还抑制 MAP 激酶激酶 3/6 (MKK3/6) 和混合谱系激酶 3 的磷酸化。
T7786	Tryptanthrin	DNA gyrase	DNA Damage/DNA Repair
	Tryptanthrin 是一种口服具有活性的细胞内Leukotriene (LT) biosynthesis 抑制剂。它能够降低大鼠胸膜炎模型中的 LTB4 水平，并抑制人全血中Leukotriene 的形成 (IC50= 10 µM)。
T3918	Ginsenoside Rb3 人参皂苷 Rb3,Gypenoside IV,人参皂苷Rb3	NF-κB; COX; NO Synthase	Immunology/Inflammation; Neuroscience; NF-κB
	Ginsenoside Rb3 (Gypenoside IV) 是从三七中提取的一种天然产物。它在 293T 细胞系中抑制 TNFα 诱导的NF-κB 转录活性，IC50为 8.2 μM。它还抑制COX-2和iNOSmRNA 的诱导。
T3779	Crocin II Crocin 2,西红花苷II,Crocetin gentiobiosylglucosyl ester,藏红花,Tricrocin,Crocin B	Caspase; COX; NO Synthase	Apoptosis; Immunology/Inflammation; Neuroscience; Proteases/Proteasome
	Crocin II (Crocetin gentiobiosylglucosyl ester) 是从栀子果实中分离出来的一种天然产物，具有抗氧化、抗癌和抗抑郁活性。它抑制 iNOS 和 COX-2的蛋白质和 m-RNA 的表达，还抑制NO 产生，IC50值为 31.1 μM。
T3805	Prim-O-glucosylcimifugin 升麻苷,Cimifugin beta-D-glucopyranoside,Cimifugin 7-glucoside	TNF; COX; JAK; NO Synthase	Angiogenesis; Apoptosis; Chromatin/Epigenetic; Immunology/Inflammation; JAK/STAT signaling; Neuroscience; Stem Cells
	Prim-O-glucosylcimifugin (Cimifugin 7-glucoside) 具有强效的抗炎作用。通过调节 JAK2/STAT3 信号传导可抑制iNOS 和COX-2表达。
T3811	Ginsenoside C-K 20(S)-人参皂苷 C-K,Ginsenoside compound K,Ginsenoside K,人参皂苷 C-K	P450; cell cycle arrest; COX; NO Synthase	Cell Cycle/Checkpoint; Immunology/Inflammation; Metabolism; Neuroscience
	Ginsenoside C-K (Ginsenoside K) 是 Ginsenoside Rb1 的细菌代谢物，可通过抑制诱生型一氧化氮合酶和COX-2来发挥抗炎作用。它在人肝微粒体中抑制CYP2C9和CYP2A6活性，IC50分别为 32.0±3.6 和 63.6±4.2 μM。
T3S0401	Piceatannol 3'-O-glucoside 白皮杉醇 3'-O-葡萄糖苷,Piceatannol 3-glycoside,Quzhaqigan,曲札茋苷、白皮杉醇-3'-O-葡萄糖苷	Arginase; NO Synthase	Immunology/Inflammation
	Piceatannol 3'-O-glucoside (Piceatannol 3-glycoside) 是大黄的一种活性成分，通过抑制精氨酸酶活性激活内皮细胞一氧化氮合酶，抑制Arginase I 和Arginase II，IC50值分别为 11.22 和 11.06 μM。它可增加肺血氧分压，减少肺间质水肿，从而保护肺损伤。
T2758	Madecassic acid 6-Deoxy-L-Galactose,羟基积雪草酸,L-Fucose,Brahmic acid,L-fucopyranose	Others; TNF; COX; NO Synthase; Interleukin	Apoptosis; Immunology/Inflammation; Neuroscience; Others
	Madecassic acid (L-fucopyranose) 是分离自积雪草的一种天然产物，抑制iNOS、COX-2、TNF-α、IL-1beta 和IL-6，可通过在 RAW 264.7 巨噬细胞中下调NF-κB 激活而具有抗炎作用。
T5S0754	Isoquercetin 3-Glucosylquercetin,Hirsutrin,Isoquercitrin,异槲皮苷,Quercetin 3-o-glucopyranoside,槲皮素-3-葡萄糖苷	NF-κB; Wnt/beta-catenin; NO Synthase	Cytoskeletal Signaling; Immunology/Inflammation; NF-κB; Stem Cells
	Isoquercetin (3-Glucosylquercetin) 是天然存在的多酚，具有抗氧化，抗增殖和抗炎特性。它通过调节核因子-κB 转录调节系统调节一氧化氮合酶 2 的表达。它通过 Nrf2/ARE 抗氧化剂信号传导途径减轻乙醇诱导的肝毒性，氧化应激和炎症反应。它具有高生物利用度和低毒性，是预防糖尿病妊娠出生缺陷的有希望的候选药物。
T0670	L-Arginine hydrochloride (S)-(+)-Arginine hydrochloride,左旋精氨酸单盐酸盐,L-Arginine HCl (L-Arg),L-arginine monohydrochloride	Amino Acids and Derivatives; Endogenous Metabolite; NO Synthase	Immunology/Inflammation; Metabolism
	L-Arginine hydrochloride 为合成一氧化氮的氮供体，是血管扩张剂。
TN1102	Physalin L 酸浆苦味素L,酸浆苦味素 L	Others; NO Synthase	Immunology/Inflammation; Others
	Physalin L 抑制巨噬细胞中 LPS 诱导的 NO 生成，平均抑制率是 70.97%。它具有抗炎作用。
TN1109	3-O-Acetyl-16α-hydroxydehydrotrametenolic acid 3-O-Acetyl-16 alpha-hydroxydehydrotrametenolic acid,3-O-乙酰基-16Α-羟基松苓新酸	NOS; NO Synthase; Prostaglandin Receptor	GPCR/G Protein; Immunology/Inflammation
	3-O-Acetyl-16α-hydroxydehydrotrametenolic acid (3-O-Acetyl-16 alpha-hydroxydehydrotrametenolic acid) 是三萜类化合物。它能够作用于 LPS 刺激的 Raw264.7 细胞，减少NO 产生和 iNOS 表达，具有消炎作用。
T38248	2-Ethylpyrazine	Endogenous Metabolite; NO Synthase	Immunology/Inflammation; Metabolism
	2-Ethylpyrazine 存在与烘焙后的咖啡豆中，是一种挥发性化合物。2-Ethylpyrazine 通过内皮衍生的松弛因子的活动诱导血管舒张。2-Ethylpyrazine 通过内皮内皮NO 合酶的作用激活NO 合成。2-Ethylpyrazine 通过诱导NO 释放和增加外周血流量来诱导血管舒张。
T7344	SDMA NG,NG'-Dimethyl-L-arginine,Symmetric dimethylarginine,对称N,N-二甲基精氨酸	Endogenous Metabolite	Metabolism
	SDMA (Symmetric dimethylarginine) 是一氧化氮 (NO) 合酶的内源性抑制剂。
T3794	Pentagalloylglucose Penta-O-galloyl-β-D-glucose,1,2,3,4,6-O-Pentagalloylglucose,1,2,3,4,6-Penta-O-galloyl-beta-D-glucopyranose,1,2,3,4,6-五没食子酰葡萄糖	Influenza Virus	Microbiology/Virology
	1,2,3,4,6-O-Pentagalloylglucose (Penta-O-galloyl-β-D-glucose) 存在于多种植物中，具有重要的药理作用。Pentagalloylglucose 表现出显著的抗狂犬病病毒 (RABV) 活性。
T75616	Inflexuside A
	Inflexuside A为一种可从蛇床子地上部分提取的冷杉烷二萜。Inflexuside B在RAW264.7巨噬细胞中强烈抑制由脂多糖(LPS)激活的一氧化氮(NO Synthase)产生。
T75615	Inflexuside B
	Inflexuside B为一种冷杉烷二萜，其源自蛇床子地上部分的提取。本化合物在RAW264.7巨噬细胞中，可显著抑制由脂多糖(LPS)激活产生的一氧化氮(NO Synthase)。
TN3318	9-Hydroxy-alpha-lapachone	Antifection	Microbiology/Virology
	9-Hydroxy-alpha-lapachone can highly inhibit the growth of H. pylori, it exhibits potent inhibitory activity against H. pylori Cystathionine gamma-synthase, with IC(50) values of 4.64 microM. It may have anti-inflammatory activity, it exhibits potent inhi
TN2534	1-Hydroxy-2,3,5-trimethoxyxanthone	IκB/IKK; Calcium Channel; NOS; 5-HT Receptor; COX	GPCR/G Protein; Immunology/Inflammation; Membrane transporter/Ion channel; Metabolism; Neuroscience; NF-κB
	1-Hydroxy-2,3,5-trimethoxyxanthone (HM-1) has vasodilator action ,which involves both an endothelium-dependent mechanism involving NO and an endothelium-independent mechanism by inhibiting Ca(2+) influx through L-type voltage-operated Ca(2+) channels; a minor contribution to the effects of HM-1 may be related to inhibition of the protein kinase C-mediated release of intracellular Ca(2+) stores. HM-1,at the concentration of 1 ug/mL, can effectively inhibit the osteoclast differentiation in a co-c...

天然产物

Cat.No: TQ0301

Target: NO Synthase

Cat.No: T6S1665

Target: Others, NO Synthase

Cat.No: T6S2023

Target: Others, COX, NO Synthase

Asymmetric dimethylarginine

Cat.No: T7682

Target: Endogenous Metabolite, NO Synthase, NOD

Epibetulinic acid

Cat.No: T2S0765

Target: NO Synthase, Prostaglandin Receptor

Cat.No: T3847

Synonym: Asperulosid,车叶草苷

Target: Others, NO Synthase

Dehydroevodiamine

Cat.No: T2S2335

Synonym: DHED,去氢吴茱萸碱

Target: Others, NF-κB, COX, PGE Synthase, NO Synthase

L-Canavanine sulfate

Cat.No: T5838

Target: NO Synthase, NOD

Cat.No: T5S0285

Synonym: 肉苁蓉苷 A,肉苁蓉苷A

Target: Others

Cat.No: T5681

Synonym: 咖啡酸乙酯,ETHYL 3,4-DIHYDROXYCINNAMATE

Target: NF-κB, COX, PGE Synthase, NO Synthase

Agmatine sulfate

Cat.No: T4808

Synonym: Agmatine sulfate salt,硫酸胍基丁胺

Target: Endogenous Metabolite, NO Synthase, Imidazoline Receptor

Cat.No: T7597

Synonym: L-生物喋呤,L-Biopterin

Target: Endogenous Metabolite, NO Synthase, NOD

Cat.No: T2791

Synonym: 柳穿鱼叶苷,大蓟苷

Target: Apoptosis, Others, NO Synthase, Prostaglandin Receptor, Interleukin

Cat.No: TN2139

Synonym: 鸦胆子苦醇,王百合苷 B

Target: NOS, COX, NO Synthase

Chondroitin sulfate

Cat.No: T2980

Synonym: Chonsurid,Chondroitin polysulfate,硫酸软骨素

Target: MMP, Others, Endogenous Metabolite, NO Synthase

Cat.No: T3S0364

Synonym: L-精氨酸,L-Arg,(S)-(+)-Arginine

Target: IL Receptor, Endogenous Metabolite, NO Synthase

Cat.No: T1310

Synonym: Thiouracil,硫代由雪,Deracil,2-硫脲嘧啶

Target: Thyroid hormone receptor(THR), NO Synthase

Cat.No: TN1373

Synonym: Alpha-caryophyllene,ALPHA-律草烯

Target: TNF, NOS, COX

Ethyl 3,4-dihydroxybenzoate

Cat.No: T5684

Target: Apoptosis, Others, Reactive Oxygen Species, HIF/HIF Prolyl-Hydroxylase, NO Synthase, Autophagy

anemarsaponin B

Cat.No: T7030

Synonym: 知母皂苷B,知母皂苷 B

Target: p38 MAPK, NF-κB, MEK, COX, NO Synthase

Cat.No: T7786

Target: DNA gyrase

Ginsenoside Rb3

Cat.No: T3918

Synonym: 人参皂苷 Rb3,Gypenoside IV,人参皂苷Rb3

Target: NF-κB, COX, NO Synthase

Cat.No: T3779

Synonym: Crocin 2,西红花苷II,Crocetin gentiobiosylglucosyl ester,藏红花,Tricrocin,Crocin B

Target: Caspase, COX, NO Synthase

Prim-O-glucosylcimifugin

Cat.No: T3805

Synonym: 升麻苷,Cimifugin beta-D-glucopyranoside,Cimifugin 7-glucoside

Target: TNF, COX, JAK, NO Synthase

Ginsenoside C-K

Cat.No: T3811

Synonym: 20(S)-人参皂苷 C-K,Ginsenoside compound K,Ginsenoside K,人参皂苷 C-K

Target: P450, cell cycle arrest, COX, NO Synthase

Piceatannol 3'-O-glucoside

Cat.No: T3S0401

Synonym: 白皮杉醇 3'-O-葡萄糖苷,Piceatannol 3-glycoside,Quzhaqigan,曲札茋苷、白皮杉醇-3'-O-葡萄糖苷

Target: Arginase, NO Synthase

Madecassic acid

Cat.No: T2758

Synonym: 6-Deoxy-L-Galactose,羟基积雪草酸,L-Fucose,Brahmic acid,L-fucopyranose

Target: Others, TNF, COX, NO Synthase, Interleukin

Cat.No: T5S0754

Synonym: 3-Glucosylquercetin,Hirsutrin,Isoquercitrin,异槲皮苷,Quercetin 3-o-glucopyranoside,槲皮素-3-葡萄糖苷

Target: NF-κB, Wnt/beta-catenin, NO Synthase

L-Arginine hydrochloride

Cat.No: T0670

Synonym: (S)-(+)-Arginine hydrochloride,左旋精氨酸单盐酸盐,L-Arginine HCl (L-Arg),L-arginine monohydrochloride

Target: Amino Acids and Derivatives, Endogenous Metabolite, NO Synthase

Cat.No: TN1102

Synonym: 酸浆苦味素L,酸浆苦味素 L

Target: Others, NO Synthase

3-O-Acetyl-16α-hydroxydehydrotrametenolic acid

Cat.No: TN1109

Synonym: 3-O-Acetyl-16 alpha-hydroxydehydrotrametenolic acid,3-O-乙酰基-16Α-羟基松苓新酸

Target: NOS, NO Synthase, Prostaglandin Receptor

2-Ethylpyrazine

Cat.No: T38248

Target: Endogenous Metabolite, NO Synthase

Cat.No: T7344

Synonym: NG,NG'-Dimethyl-L-arginine,Symmetric dimethylarginine,对称N,N-二甲基精氨酸

Target: Endogenous Metabolite

Pentagalloylglucose

Cat.No: T3794

Synonym: Penta-O-galloyl-β-D-glucose,1,2,3,4,6-O-Pentagalloylglucose,1,2,3,4,6-Penta-O-galloyl-beta-D-glucopyranose,1,2,3,4,6-五没食子酰葡萄糖

Target: Influenza Virus

Cat.No: T75616

Cat.No: T75615

9-Hydroxy-alpha-lapachone

Cat.No: TN3318

Target: Antifection

1-Hydroxy-2,3,5-trimethoxyxanthone

Cat.No: TN2534

Target: IκB/IKK, Calcium Channel, NOS, 5-HT Receptor, COX

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